Ectopic expression of DREF1–125 inhibits DNA replication of cells in the second mitotic wave. Fumiko Hirose et al. Mol. Cell. Biol. 1999; doi:10.1128/MCB.19.9.6020 [Drosophila eye imaginal disc – image edited]
Holometaboly is the materially observant description of an insect’s metamorphosis in the pupa state. It commences by the larva digesting its own corporeal tissue, turning itself into an energetic pulp from which the insect’s form is subsequently modeled. During this autodigestion, imaginal discs – cell pods existing quiescently in the larva form – activate, shifting position in the liquefying body to become the seed points for the future insect’s wings, legs, eyes, genitalia and other features.
Rendering structural dissolution in one view with the mobilization of formal information, holometaboly presents a metaphor for a conception of deep change in which entropic degradation appears interactive with, rather than paradoxical to, the continuity and development of information clusters, however unmoored and displaced. In its anti-roadmap roadmap, deep change appears as neither catastrophic nor a knowable project, but as a dynamic in which chaotic and mnemonic forms and actions are purposefully allied, and in which prediction can be performed through and because of the anti-rational erosion it is predicated upon.
Through the lens of the imaginal disc, ɬɾąŋʂɠɛŋıƈ 2021 has set out to explore the interdependence of knowing and unknowing at the membranes between built and natural environments – ways of detaching and connecting, pathways of searching and researching, acts of resolving and dissolving, motions of decoding and encoding, merits of remembering and forgetting, …